DynaPro Plate Reader III

Wyatt DynaPro Plate Reader III P/N WPR3-01

***This instrument was tested to specifications. Unit is in excellent condition with little to no-wear from normal use. Buyer can expect the same item pictured with 30-day warranty. See photos for details. 

The DynaPro Plate Reader offers dynamic light scattering (DLS) and static light scattering (SLS) measurements of the size, molecular weight, concentration and interactions of proteins, nanoparticles and other macromolecules in situ in industry-standard microwell plates. No liquid handling occurs after dispensing into the plates, to maximize throughput and minimize sample carryover. This ground-breaking instrument provides rapid optimization of the formulation process for:

• Biotherapeutics such as monoclonal antibodies and virus-like particles (VLPs)
• Nanoparticle drug delivery vehicles including liposomes and conjugated gold NPs
• Viral and non-viral gene vectors like AAV, adenovirus, lentivirus and LNP

A wealth of applications

The DynaPro Plate Reader provides unparalleled levels of ease-of-use, productivity, reproducibility, and flexibility in order to address additional demanding applications such as:

• Assessing aggregation or oligomerization
• Quantifying AAV titer for multiple processes
• Determining protein stability-indicating parameters such as thermal denaturation and colloidal stability
• Optimizing protein crystallization
• Screening high-concentration protein solutions for reversible association and viscosity

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Key features

• Measure hydrodynamic radius from 0.5 nm to 1000 nm
• Determine particle concentration for particles up to 320 nm in diameter
• Sensitivity for size down to 0.125 mg/mL lysozyme
• Measure weight-average molar mass from 1 to 1000 kDa
• Industry-standard microwell plates of 96, 384 or 1536 wells
• Sample volume from 4 μL to 150 μL
• All measurements made in situ in the wells
• Temperature ramps from 4 °C to 85 °C
• Integrates with plate-based liquid handling robotics

Speed up size and stability screening with high-throughput dynamic light scattering

Revolutionize your biotherapeutic and nanoparticle development with high- throughput dynamic light scattering (HT-DLS) and the automated DynaPro^® Plate Reader. The DynaPro excels at high-throughput sizing and screening of biopharmaceutical and nanoparticle formulations to enable novel workflows that simply would not be possible with other DLS instruments.

The DynaPro Plate Reader
offers a complete solution in a standard well plate

• Discover small-molecule and peptide drugs
• Develop stable biopharmaceuticals
• Formulate nanoparticles
• Optimize protein buffers
• Characterize gene vectors

Obtain the Complete Attribute Landscape

• Size and size distributions (r_h)
• Molar mass (M_w)
• Aggregation and stability indicators (T_onset, T_m, T_agg, k_D, A₂)
• Viscosity
• Solubility
• Titer/ particle concentration

Fast, Easy, Accurate

• Uses industry-standard 96, 384 or 1,536 microwell plates
• Sample volume as low as 4 μL
• User friendly experiment design in Dynamics
• As sensitive as a cuvette-based DLS
• First and only A₂ and M_w in a plate
• Film- or oil-based evaporation seal
• Measure from 4 ºC to 85 ºC
• Infrared wavelength not susceptible to fluorescence
• 21 CFR Part 11 compliant software

Manufacturer's Specifications: