Thermo Electron Transfer Dissociation (ETD) - parts unit

Thermo Scientific ETD Electron Transfer Dissociation for LTQ Series Mass Specs

Used - this was removed from a working MS system; it is component to a larger system, not a stand alone peice of equipment.  We cannot test this because it is not a complete system

We cannot test it before it ships,

*Please enquire if you would like to have this fully refurbished and installed by a third party specialist.

Achieve better analysis of proteins and their post-translational  modifications (PTMs) with the Thermo Scientific Electron Transfer Dissociation  (ETD) option. Unlike CID, which cleaves weakly bound modifications off the  peptide backbone, ETD induces fragmentation along the peptide backbone in a  sequence-independent manner, leaving labile modifications linked to the peptide  chain. This greatly simplifies identification of modification sites. ETD  produces primarily c- and z-type fragment ions that complement the b- and y-type  ions produced by CID, increasing sequence coverage and protein IDs.

Features:

• ETD preserves labile PTMs, allowing straightforward identification of the  peptide sequence and the site of modification
• For top-down analysis, ETD can be combined with proton transfer reaction  (PTR) which dramatically simplifies spectra from intact proteins
• For workflows that include low-mass isobaric mass tags, ETD can be combined  with pulsed-Q dissociation (PQD) which eliminates the normal low-mass cutoff
• ETD can be added to most Thermo Scientific LTQ-series ion trap and hybrid  ion trap-Orbitrap mass spectrometers
• Proteome Discoverer software includes the proprietary Z-Core database search  algorithm specifically optimized for ETD spectra
• Proteome Discoverer software can easily merge complementary CID and ETD  results to maximize protein sequence coverage.

Includes:

• Thermo Electron Transfer Dissociation (ETD)
• Works on:
  • LTQ XL
  • LTQ Velos
  • LTQ Velos Pro
• Additional XCalibur Software NOT required